• From the same perspective previous studies by Sajdyk

  2020-08-06

  

  From the same perspective, previous studies by Sajdyk and colleagues (Sajdyk et al., 1999) and Spiga and colleagues (Spiga et al., 2006) have shown that the administration of CRF or urocortin 1 (a selective agonist for CRF1 and CRF2 receptors but with a higher affinity for the CRF1 receptor) into th

• br The need for modified

  2020-08-06

  

  The need for modified therapeutic proteins and why they need to last longer in the body Chemical and structural changes in therapeutic proteins are possible and are carried out frequently to accomplish pharmacological or clinical benefit. Such modifications are essential as the drug needs to pas

• Maintaining the sensorial qualities of minimally processed f

  2020-08-06

  

  Maintaining the sensorial qualities of minimally processed fruit after processing and during the chain of distribution is very difficult. The shelf-life of cut produce is very limited due to browning of the flesh and the loss of flavour (Conway et al., 2002; Toivonen, 2006; Toivonen and Delaquis, 20

• Metronidazole Recruitment of plasminogen on to the bacterial

  2020-08-05

  

  Recruitment of plasminogen on to the bacterial surface has long been acknowledged as a mechanism involved in bacterial attachment and tissue invasion [6], [7], [8]. Plasminogen is a proenzyme which can be proteolytically activated by host tissue plasminogen activator (tPA) and urokinase into fibrino

• In line with the above results

  2020-08-05

  

  In line with the above results by Girardi and colleagues [120], Rieg et al. [108] have demonstrated that alogliptin induced natriuretic and diuretic effects in non-diabetic mice independently of GLP-1R or changes in NHE3. Accordingly, in glycogen synthase kinase 3 to exendin-4, the alogliptin-induc

• These changes in the corticolimbic system may be mediated

  2020-08-05

  

  These changes in the corticolimbic system may be mediated by the action of neuropeptide corticotropin-releasing factor (CRF), which interacts with two G-protein-coupled corticotropin-releasing factor CRF receptors, type 1 (corticotropin-releasing factor CRF1 receptor) and type 2 (corticotropin-relea

• Dopamine affects cognition especially in prefrontal cortex d

  2020-08-05

  

  Dopamine affects cognition, especially in prefrontal cortex, due to its role in attention, vigilance, sleep and arousal. Increased dopaminergic prefrontal activity/availability is associated with improved working memory, attention and other executive functions [7]. Catechol-O-methyltransferase (COMT

• br Methods br Results br Discussion It is

  2020-08-05

  

  Methods Results Discussion It is highly challenging to screen for biomarkers that address the entangled contributions of persistent virus enhancement on age-accumulated T cell aging. (Waaijer et al., 2017) (Jackson et al., 2017). As the process of T cell aging is generally subclinical and a

• This study aims to analyze the

  2020-08-05

  

  This study aims to analyze the energetic proprieties of Elephant Grass (EG) through its characterization, its conventional pyrolysis products and its catalytic pyrolysis products using WO3 supported on rice husk ash (RHA) silica and RHA-MCM-41 mesoporous materials. In addition, the study also evalua

• The individuals described here experienced corneal vasculari

  2020-08-04

  

  The individuals described here experienced corneal vascularization in early adult life. DDR2 is able to both drive and prevent angiogenesis under different conditions.21, 22, 23 The primary effect seems to be angiogenesis stimulation, but a rebound effect or overcompensation can counterbalance this.

• Not all of the biological

  2020-08-04

  

  Not all of the biological activities exhibited by progestogens (Table 1) are mediated via binding to SRs. For example, the anti-estrogenic action of progestogens in the omadacycline is due to the progestogen-bound PR suppressing ER gene expression, and consequently the ability of the cell to respon

• br Introduction Chronic rhinosinusitis CRS is a

  2020-08-04

  

  Introduction Chronic rhinosinusitis (CRS) is a significant health problem [1] and recent data have illustrated that CRS affects about 5–15% of the population in Europe and the USA [2]. Chronic rhinosinusitis with nasal polyps (CRSwNP) is considered a subgroup of CRS, a chronic inflammatory condit

• Structure similarity searches were conducted using the

  2020-08-04

  

  Structure similarity searches were conducted using the standalone version of the DALI program with the query structures scanned against a local current version of the PDB that has all chains as separate entries (Holm and Sander, 1995). The structural hits for each query were collected, even if the D

• These studies suggested that PV PVH might promote bone

  2020-08-04

  

  These studies suggested that PV/PVH might promote bone formation activities and/or inhibit bone resorption activities probably due to its anti-inflammation activity; however, the underlying mechanism remained unknown. Furthermore, it is unclear if PVH shows better activity than that of PV; this is i

• Twin studies have shown that P has moderate heritability Zuc

  2020-08-04

  

  Twin studies have shown that P has moderate heritability. Zuckerman (1989) reviewed the earlier studies of P or related traits and found a median heritability of 0.51. However, twin studies using an Eysenckian P scale have tended to estimate somewhat lower heritabilities than this, in the range 0.36

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