• According to its major function as master regulator of BA

  2022-06-18

  

  According to its major function as master regulator of BA homeostasis, FXR has been shown to have a specific tissue distribution; it is expressed along the entire gastrointestinal tract with a peak in the liver and ileum, as well as in the kidney, and adrenal glands [30], [66], [135]. Low FXR expres

• Based on this evidence future research should be directed to

  2022-06-18

  

  Based on this evidence, future research should be directed towards the identification of actual receptor oligomeric states at the analyzed cellular surfaces. The macromolecular organization of these oligomeric receptors might establish informational hubs, which relay ligand/receptor interactions in

• br G protein coupled receptor

  2022-06-18

  

  G-protein coupled receptor 40 (GPR40), also known as a free fatty lumiracoxib receptor, is dominantly expressed in pancreatic β cells and intestine K, L cells., . Besides, GPR40 is also reported to be expressed in brain, but its function is still unknown. It is well documented that GPR40 agonist

• Liver and muscle isozymes have been found

  2022-06-18

  

  Liver and muscle isozymes have been found in vertebrate tissues [2], [5], [6]. The liver FBPase is recognized as a regulatory enzyme of gluconeogenesis. The muscle isozyme participates in the glycogen synthesis from lactate and in the regulation of glycolysis [7], [8], [9]. The basic difference betw

• br STAR Methods br Acknowledgments We

  2022-06-18

  

  STAR★Methods Acknowledgments We thank Emeritus Professor Chikashi Shimoda and Professor Taro Nakamura of the National BioResource Project/Yeast Genetic Resource Center (NBRP/YGRC) at Osaka City University (Osaka, Japan) for Schizosaccharomyces pombe meiotic cDNA library, yeast plasmids, yeast

• br Materials and methods br Results br Discussion The

  2022-06-18

  

  Materials and methods Results Discussion The major findings of the present study are that: 1) the response to inverse agonists may be crossregulated by the activation of either 1423 H1 or H2 receptors, 2) histamine H1 and H2 receptor inverse agonists crossdesensitize the receptor´s respons

• Thermal analysis of the NQ peptide

  2022-06-17

  

  Thermal analysis of the NQ21 peptide was performed with the Solar CM2203 spectrofluorometer. We prepared three 1 μg/mL peptide solutions with different navitoclax bcl-w levels (5.0, 7.4, 8.5) in 0.01 M phosphate buffers. Each solution was slowly heated up from 28 °C to 54 °C with a step of 1 °C. Spe

• br Glycoengineering br The Omics perspective The publication

  2022-06-17

  

  Glycoengineering The « Omics » perspective The publication of the CHO-K1 genome sequence in 2011, followed by the publication of two Chinese hamster and six CHO cell line genomes in 2013, bring new opportunities in developing and engineering CHO Brefeldin A for improved glycoprotein production

• Finally the results in this article indicate that atomistic

  2022-06-17

  

  Finally, the results in this article indicate that atomistic MD in conjunction with computational electrophysiology and ion-permeation simulations provide a useful tool for the functional annotation of ion-channel structures. In particular, they exemplify how MD simulations in native lipid membranes

• Mubritinib Ionotropic glutamate receptors GluRs are ligand g

  2022-06-17

  

  Ionotropic glutamate receptors (GluRs) are ligand-gated ion channels that mediate information processing at the majority of excitatory synapses in the brain and participate in such physiological processes as learning and memory, development and maintenance of cellular connections, and pain perceptio

• Tolcapone Ghrelin is a brain gut

  2022-06-17

  

  Ghrelin is a brain-gut peptide hormone secreted from the stomach to stimulate food intake by acting on its receptor, growth hormone secretagogue receptor (GHSR). GHSR is expressed throughout the brain and in NPY/AgRP neurons in the ARC (Cowley et al., 2003, Willesen et al., 1999). Ghrelin-expressin

• br Discussion According to the

  2022-06-17

  

  Discussion According to the generally accepted notion which originated from the study of ATP-depleted corticotropin releasing factor the changes in Ca2+ homeostasis induced by ATP depletion and leading to the activation of the Gárdos effect are due to the inhibition of Ca2+ pumping, and the subs

• Cyclic Pifithrin-α hydrobromide br During cardiac ischaemia

  2022-06-17

  

  During cardiac ischaemia, a decrease in GJ coupling is observed, which results in slower conduction of electrical impulses and a higher risk of arrhythmias.[13], [20] In Huntington’s disease an increase in the Cyclic Pifithrin-α hydrobromide of 5 Cxs was observed in the astrocytes in the brain, su

• In conclusion starting from the weakly potent

  2022-06-17

  

  In conclusion, starting from the weakly potent GSM , exploration of various spacer groups between the triazole ring and the aromatic ezh2 pathway led to the discovery of a new series of potent gamma secretase modulators, with an improved drug-like profile—compared with the originally reported series

• br Acknowledgements This work was

  2022-06-17

  

  Acknowledgements This work was supported by grants of the Argentine National Research Council (CONICET, PIP 0662). The authors express their appreciation to the Transmission Electron Microscopy Service (MET) of the Faculty of Veterinary Medicine of the National University of La Plata (Argentina)

11001 records 115/734 page Previous Next First page 上5页 111112113114115 下5页 Last page